Molecular Insights Into Regulatory T-Cell Adaptation to Self, Environment, and Host Tissues: Plasticity or Loss of Function in Autoimmune Disease

There has been much interest in the ability of regulatory T cells (Treg) to switch function in vivo, either as a result of genetic risk of disease or in response to environmental and metabolic cues. The relationship between levels of FOXP3 and functional fitness plays a significant part in this plas...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Cheryl Y. Brown, Timothy Sadlon, Christopher M. Hope, Ying Y. Wong, Soon Wong, Ning Liu, Holly Withers, Katherine Brown, Veronika Bandara, Batjargal Gundsambuu, Stephen Pederson, James Breen, Sarah Anne Robertson, Alistair Forrest, Marc Beyer, Simon Charles Barry
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2020-09-01
Subjects:	Treg FOXP3 gene regulation genetic risk of disease T-cell fate T-cell plasticity
Online Access:	https://www.frontiersin.org/article/10.3389/fimmu.2020.01269/full