Neutrophil Elastase Increases Vascular Permeability and Leukocyte Transmigration in Cultured Endothelial Cells and Obese Mice

Neutrophil elastase (NE) plays a pivotal role in inflammation. However, the mechanism underlying NE-mediated inflammation in obesity remains unclear. Here, we report that NE activates protease-activated receptor-2 (PAR2), stimulates actin filament (F-actin) formation, decreases intercellular junctio...

詳細記述

書誌詳細

出版年:	Cells
主要な著者:	Chinchu Jagadan Ushakumari, Qiong L. Zhou, Yu-Hua Wang, Sijia Na, Michael C. Rigor, Cindy Y. Zhou, Max K. Kroll, Benjamin D. Lin, Zhen Y. Jiang
フォーマット:	論文
言語:	英語
出版事項:	MDPI AG 2022-07-01
主題:	neutrophil elastase vascular endothelial injury obesity neutrophils systemic inflammation
オンライン･アクセス:	https://www.mdpi.com/2073-4409/11/15/2288