Engineering M13 bacteriophage to display HER2 mimotopes on pVIII for vaccine development

Abstract HER2-positive breast cancer is a subtype characterized by overexpression of the human epidermal growth factor receptor 2 (HER2), which is associated with aggressive tumor growth and poor prognosis. Peptide mimics of HER2 epitopes, recognized by tumor growth-inhibitory antibodies like trastu...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Narmin Nazeri, Yadollah Bahrami, Ebrahim Barzegari, Mohammad Mohammadi, Fatemeh Kazemi-Lomedasht, Masoumeh Rajabibazl, Sara Mohammadzadeh
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-07-01
Subjects:	HER2 Trastuzumab Mimotope Phage display Bacteriophage
Online Access:	https://doi.org/10.1038/s41598-025-08032-z