Molecular dissection of PI3Kβ synergistic activation by receptor tyrosine kinases, GβGγ, and Rho-family GTPases

Phosphoinositide 3-kinase (PI3K) beta (PI3Kβ) is functionally unique in the ability to integrate signals derived from receptor tyrosine kinases (RTKs), G-protein coupled receptors, and Rho-family GTPases. The mechanism by which PI3Kβ prioritizes interactions with various membrane-tethered signaling...

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Bibliographic Details

Published in:	eLife
Main Authors:	Benjamin R Duewell, Naomi E Wilson, Gabriela M Bailey, Sarah E Peabody, Scott D Hansen
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2024-05-01
Subjects:	phosphoinositide 3-kinase phosphatidylinositol phosphate lipids Rho GTPases GPCRs receptor tyrosine kinases G-proteins
Online Access:	https://elifesciences.org/articles/88991