Chronic oxidative stress promotes H2AX protein degradation and enhances chemosensitivity in breast cancer patients

Abstract Anti‐cancer drugs often increase reactive oxygen species (ROS) and cause DNA damage. Here, we highlight a new cross talk between chronic oxidative stress and the histone variant H2AX, a key player in DNA repair. We observe that persistent accumulation of ROS, due to a deficient JunD‐/Nrf2‐a...

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Bibliographic Details

Published in:	EMBO Molecular Medicine
Main Authors:	Tina Gruosso, Virginie Mieulet, Melissa Cardon, Brigitte Bourachot, Yann Kieffer, Flavien Devun, Thierry Dubois, Marie Dutreix, Anne Vincent‐Salomon, Kyle Malcolm Miller, Fatima Mechta‐Grigoriou
Format:	Article
Language:	English
Published:	Springer Nature 2016-03-01
Subjects:	JUND NRF2 RNF168 Triple‐Negative breast cancer ubiquitination
Online Access:	https://doi.org/10.15252/emmm.201505891