Effect of the gut microbiota-derived tryptophan metabolite indole-3-acetic acid in pneumonia

Abstract Gut microbiota influence the severity of pneumonia by producing metabolites that enhance systemic and pulmonary immune responses. Preclinical studies suggested that gut microbiota-derived indoles have protective effects against numerous diseases, including influenza and abdominal infections...

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Bibliographic Details

Published in:	Nature Communications
Main Authors:	Robert F. J. Kullberg, Christine C. A. van Linge, Bastiaan W. Haak, Prasanjit S. Paul, Joe M. Butler, Nora Wolff, Tjitske S. R. van Engelen, Jonne J. Sikkens, Marije K. Bomers, Antoine Lefèvre, Olaf L. Cremer, Joris J.T.H. Roelofs, Bruno Sovran, René van den Wijngaard, Alex F. de Vos, Wouter J. de Jonge, Tom van der Poll, W. Joost Wiersinga
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-09-01
Online Access:	https://doi.org/10.1038/s41467-025-63611-y