Optical control of PIEZO1 channels

PIEZO proteins are large, mechanically-activated trimeric ion channels. Here the authors report a light-gated mouse PIEZO1 channel, mOP1, whereby an azobenzene-based photoswitch covalently localised at the extracellular apex of a transmembrane helix, rapidly triggers channel gating on light irradiat...

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Bibliographic Details
Published in:Nature Communications
Main Authors: Francisco Andrés Peralta, Mélaine Balcon, Adeline Martz, Deniza Biljali, Federico Cevoli, Benoit Arnould, Antoine Taly, Thierry Chataigneau, Thomas Grutter
Format: Article
Language:English
Published: Nature Portfolio 2023-03-01
Online Access:https://doi.org/10.1038/s41467-023-36931-0

Internet

https://doi.org/10.1038/s41467-023-36931-0

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