Gain-of-Function Properties of a Dynamin 2 Mutant Implicated in Charcot-Marie-Tooth Disease

Mutations in the gene encoding dynamin 2 (DNM2), a GTPase that catalyzes membrane constriction and fission, are associated with two autosomal-dominant motor disorders, Charcot-Marie-Tooth disease (CMT) and centronuclear myopathy (CNM), which affect nerve and muscle, respectively. Many of these mutat...

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发表在:	Frontiers in Cellular Neuroscience
Main Authors:	Tara C. Tassin, Barbara Barylko, Per Niklas Hedde, Yan Chen, Derk D. Binns, Nicholas G. James, Joachim D. Mueller, David M. Jameson, Ronald Taussig, Joseph P. Albanesi
格式:	文件
语言:	英语
出版:	Frontiers Media S.A. 2021-10-01
主题:	dynamin Charcot-Marie-Tooth disease centronuclear myopathy tyrosine phosphorylation FLIM/FRET fluorescence fluctuation spectroscopy
在线阅读:	https://www.frontiersin.org/articles/10.3389/fncel.2021.745940/full