Rab7a is required to degrade select blood-brain barrier junctional proteins after ischemic stroke

Abstract The integrity of adherens and tight junctions is critical for blood-brain barrier (BBB) function in the healthy brain. Disassembly of cell junctions due to degradation of adherens and tight junction-associated proteins leads to acute BBB dysfunction after ischemic stroke, but the mechanisms...

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發表在:	Acta Neuropathologica Communications
Main Authors:	Azzurra Cottarelli, Danny Jamoul, Mary Claire Tuohy, Sanjid Shahriar, Michael Glendinning, Grace Prochilo, Aimee L. Edinger, Ahmet Arac, Dritan Agalliu
格式:	Article
語言:	英语
出版:	BMC 2025-09-01
主題:	Rab7a Tight junctions Adherens junctions Blood-brain barrier Ischemic stroke Inflammation
在線閱讀:	https://doi.org/10.1186/s40478-025-02125-6