SARM1 Promotes Photoreceptor Degeneration in an Oxidative Stress Model of Retinal Degeneration

SARM1 (sterile alpha and armadillo motif-containing protein) is a highly conserved Toll/IL-1 Receptor (TIR) adaptor with important roles in mediating immune responses. Studies in the brain have shown that SARM1 plays a role in induction of neuronal axon degeneration in response to a variety of injur...

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Bibliographic Details

Published in:	Frontiers in Neuroscience
Main Authors:	Luke Gibbons, Ema Ozaki, Chris Greene, Anne Trappe, Michael Carty, Judith A. Coppinger, Andrew G. Bowie, Matthew Campbell, Sarah L. Doyle
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-04-01
Subjects:	SARM1 sodium iodate retinal degeneration photoreceptors cell death caspase-3
Online Access:	https://www.frontiersin.org/articles/10.3389/fnins.2022.852114/full