Is magnetic resonance imaging a plausible biomarker for upper motor neuron degeneration in amyotrophic lateral sclerosis/primary lateral sclerosis or merely a useful paraclinical tool to exclude mimic syndromes? A critical review of imaging applicability in clinical routine

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that affects motor neurons in the cerebral cortex, brainstem, and spinal cord, brain regions in which conventional magnetic resonance imaging is often uninformative. Although the mean time from symptom onset to diagnosis is est...

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Bibliographic Details

Published in:	Arquivos de Neuro-Psiquiatria
Main Authors:	Antonio José da Rocha, Antonio Carlos Martins Maia Júnior
Format:	Article
Language:	English
Published:	Thieme Revinter Publicações 2012-07-01
Subjects:	esclerose lateral amiotrófica esclerose lateral primária imagem de tensor por difusão espectroscopia de prótons ressonância magnética
Online Access:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2012000700012&lng=en&tlng=en