New Multifunctional Agents Based on Conjugates of 4-Amino-2,3-polymethylenequinoline and Butylated Hydroxytoluene for Alzheimer’s Disease Treatment

New hybrids of 4-amino-2,3-polymethylenequinoline with different sizes of the aliphatic ring linked to butylated hydroxytoluene (BHT) by enaminoalkyl (<b>7</b>) or aminoalkyl (<b>8</b>) spacers were synthesized as potential multifunctional agents for Alzheimer’s disease (AD)...

Full description

Bibliographic Details

Published in:	Molecules
Main Authors:	Galina F. Makhaeva, Nadezhda V. Kovaleva, Elena V. Rudakova, Natalia P. Boltneva, Sofya V. Lushchekina, Irina I. Faingold, Darya A. Poletaeva, Yuliya V. Soldatova, Raisa A. Kotelnikova, Igor V. Serkov, Anatoly K. Ustinov, Alexey N. Proshin, Eugene V. Radchenko, Vladimir A. Palyulin, Rudy J. Richardson
Format:	Article
Language:	English
Published:	MDPI AG 2020-12-01
Subjects:	4-amino-2,3-polymethylenequinolines butylated hydroxytoluene (BHT) acetylcholinesterase (AChE) butyrylcholinesterase (BChE) antioxidants neuroprotection
Online Access:	https://www.mdpi.com/1420-3049/25/24/5891