Role of lactate dehydrogenase A in the regulation of podocyte metabolism and glucose uptake under hyperglycemic conditions

Abstract Lactate is a cellular product of glycolytic metabolism, serving as both an additional oxidative energy substrate and a signaling molecule in metabolic regulation. Plasma lactate levels are elevated in diabetes, and chronic extracellular lactic acidosis is recognized as a negative prognostic...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Audzeyenka Irena, Grochowalska Klaudia, Szrejder Maria, Kulesza Tomasz, Rachubik Patrycja, Rogacka Dorota, Piwkowska Agnieszka
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-04-01
Subjects:	Lactate dehydrogenase Hyperglycemia Insulin Glycolysis Glucose uptake Lactate
Online Access:	https://doi.org/10.1038/s41598-025-98797-0