MICA and NKG2D gene polymorphisms influence graft survival, and response to therapy in kidney transplantation

BackgroundAntibody-mediated rejection is a significant cause of kidney transplant failure. Recent studies have shown that the MHC class I MICA gene influences the transplantation outcome. However, the role of the primary MICA receptor, NKG2D, has yet to be explored.AimWe aimed to investigate the cor...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Roberto Littera, Stefano Mocci, Davide Argiolas, Letizia Littarru, Sara Lai, Maurizio Melis, Celeste Sanna, Caterina Mereu, Michela Lorrai, Alessia Mascia, Andrea Angioi, Giacomo Mascia, Valeria Matta, Nicola Lepori, Matteo Floris, Cristina Manieli, Paola Bianco, Daniela Onnis, Stefania Rassu, Silvia Deidda, Mauro Giovanni Carta, Erika Giuressi, Andrea Perra, Luchino Chessa, Sabrina Giglio, Antonello Pani
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-11-01
Subjects:	kidney transplant antibody-mediated rejection MICA NKG2D DSA
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1440887/full