The roles of AIM2 in neurodegenerative diseases: insights and therapeutic implications

AIM2, a cytosolic innate immune receptor, has the capability to recognize double-stranded DNA (dsDNA). This paper delineates the structural features of AIM2 and its mechanisms of activation, emphasizing its capacity to detect cytosolic DNA and initiate inflammasome assembly. Additionally, we explore...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Kai Yang, Xi Wang, Hanyu Pan, Xinqing Wang, Yunhan Hu, Yihe Yao, Xinyue Zhao, Taolei Sun
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-07-01
Subjects:	inflammasome AIM2 neurodegenerative disease Alzheimer’s disease Parkinson’s disease
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1441385/full