A novel in vitro cell model of the proteinase/antiproteinase balance observed in alpha-1 antitrypsin deficiency

Background: Alpha-1 antitrypsin deficiency (AATD) is a genetic condition resulting from mutations in the alpha-1 antitrypsin (AAT) protein, a major systemic antiproteinase, resulting in reduced/no release of AAT, disrupting the proteinase/antiproteinase balance. A sustained imbalance can cause struc...

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Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Celine H. Chen, Helena Crisford, Aaron Scott, Elizabeth Sapey, Robert A. Stockley
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-07-01
Subjects:	neutrophil elastase proteinase 3 proof of concept MPH966 alpha-1 antitrypsin deficiency
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2024.1421598/full