Rational Function-Based Approach for Integrating Tableting Reduced-Order Models with Upstream Unit Operations: Dry Granulation Case Study

We present a systematic and automatic approach for integrating tableting reduced-order models with upstream unit operations. The approach not only identifies the upstream critical material attributes and process parameters that describe the coupling to the first order and, possibly, the second order...

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Bibliographic Details

Published in:	Pharmaceuticals
Main Authors:	Sunidhi Bachawala, Rexonni B. Lagare, Abigail B. Delaney, Zoltan K. Nagy, Gintaras V. Reklaitis, Marcial Gonzalez
Format:	Article
Language:	English
Published:	MDPI AG 2024-08-01
Subjects:	dry granulation tableting reduced-order models bivariate rational functions granule size distribution ribbon density
Online Access:	https://www.mdpi.com/1424-8247/17/9/1158