Identification and neuroprotective properties of NA‐184, a calpain‐2 inhibitor

Abstract Our laboratory has shown that calpain‐2 activation in the brain following acute injury is directly related to neuronal damage and the long‐term functional consequences of the injury, while calpain‐1 activation is generally neuroprotective and calpain‐1 deletion exacerbates neuronal injury....

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Bibliographic Details

Published in:	Pharmacology Research & Perspectives
Main Authors:	Michel Baudry, Yubin Wang, Xiaoning Bi, Yun Lyna Luo, Zhijun Wang, Zeechan Kamal, Alexander Shirokov, Ed Sullivan, Dennis Lagasca, Hany Khalil, Gary Lee, Kathy Fosnaugh, Philippe Bey, Shujaath Mehdi, Greg Coulter
Format:	Article
Language:	English
Published:	Wiley 2024-04-01
Subjects:	calpain epimerization neurodegeneration pharmacokinetics traumatic brain injury
Online Access:	https://doi.org/10.1002/prp2.1181