System identification of signaling dependent gene expression with different time-scale data.

Cells decode information of signaling activation at a scale of tens of minutes by downstream gene expression with a scale of hours to days, leading to cell fate decisions such as cell differentiation. However, no system identification method with such different time scales exists. Here we used compr...

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Bibliographic Details

Published in:	PLoS Computational Biology
Main Authors:	Takaho Tsuchiya, Masashi Fujii, Naoki Matsuda, Katsuyuki Kunida, Shinsuke Uda, Hiroyuki Kubota, Katsumi Konishi, Shinya Kuroda
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2017-12-01
Online Access:	http://europepmc.org/articles/PMC5760096?pdf=render