Targeting myocardial equilibrative nucleoside transporter ENT1 provides cardioprotection by enhancing myeloid Adora2b signaling

Previous studies implicate extracellular adenosine signaling in attenuating myocardial ischemia and reperfusion injury (IRI). This extracellular adenosine signaling is terminated by its uptake into cells by equilibrative nucleoside transporters (ENTs). Thus, we hypothesized that targeting ENTs would...

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出版年:	JCI Insight
主要な著者:	Wei Ruan, Jiwen Li, Seungwon Choi, Xinxin Ma, Yafen Liang, Ragini Nair, Xiaoyi Yuan, Tingting W. Mills, Holger K. Eltzschig
フォーマット:	論文
言語:	英語
出版事項:	American Society for Clinical investigation 2023-06-01
主題:	Cardiology Inflammation
オンライン･アクセス:	https://doi.org/10.1172/jci.insight.166011