Reduced synchroneity of intra-islet Ca2+ oscillations in vivo in Robo-deficient β cells

The spatial architecture of the islets of Langerhans is hypothesized to facilitate synchronized insulin secretion among β cells, yet testing this in vivo in the intact pancreas is challenging. Robo βKO mice, in which the genes Robo1 and Robo2 are deleted selectively in β cells, provide a unique mode...

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發表在:	eLife
Main Authors:	Melissa T Adams, JaeAnn M Dwulet, Jennifer K Briggs, Christopher A Reissaus, Erli Jin, Joseph M Szulczewski, Melissa R Lyman, Sophia M Sdao, Vira Kravets, Sutichot D Nimkulrat, Suzanne M Ponik, Matthew J Merrins, Raghavendra G Mirmira, Amelia K Linnemann, Richard KP Benninger, Barak Blum
格式:	Article
語言:	英语
出版:	eLife Sciences Publications Ltd 2021-07-01
主題:	islets of Langerhans beta cells robo receptors islet architecture synchronous insulin secretion intravital microscopy
在線閱讀:	https://elifesciences.org/articles/61308