Disruption of glutamine transport uncouples the NUPR1 stress-adaptation program and induces prostate cancer radiosensitivity

Abstract Background Metabolic and stress response adaptations in prostate cancer (PCa) mediate tumor resistance to radiation therapy (RT). Our study investigated the roles of glutamine (Gln) transporters SLC1A5, SLC7A5, and SLC38A1 in regulating NUPR1-mediated stress response, PCa cell survival, met...

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Published in:	Cell Communication and Signaling
Main Authors:	Uğur Kahya, Vasyl Lukiyanchuk, Ielizaveta Gorodetska, Matthias M. Weigel, Ayşe Sedef Köseer, Berke Alkan, Dragana Savic, Annett Linge, Steffen Löck, Mirko Peitzsch, Ira-Ida Skvortsova, Mechthild Krause, Anna Dubrovska
Format:	Article
Language:	English
Published:	BMC 2025-07-01
Subjects:	Prostate cancer Radiation Glutamine transporters GLS NUPR1 Oxidative stress
Online Access:	https://doi.org/10.1186/s12964-025-02344-3