Assessment of Fibrinogen Macromolecules Interaction with Red Blood Cells Membrane by Means of Laser Aggregometry, Flow Cytometry, and Optical Tweezers Combined with Microfluidics

An elevated concentration of fibrinogen in blood is a significant risk factor during many pathological diseases, as it leads to an increase in red blood cells (RBC) aggregation, resulting in hemorheological disorders. Despite the biomedical importance, the mechanisms of fibrinogen-induced RBC aggreg...

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Bibliographic Details

Published in:	Biomolecules
Main Authors:	Alexey N. Semenov, Andrei E. Lugovtsov, Evgeny A. Shirshin, Boris P. Yakimov, Petr B. Ermolinskiy, Polina Y. Bikmulina, Denis S. Kudryavtsev, Peter S. Timashev, Alexei V. Muravyov, Christian Wagner, Sehyun Shin, Alexander V. Priezzhev
Format:	Article
Language:	English
Published:	MDPI AG 2020-10-01
Subjects:	fibrinogen macromolecules RBC membrane optical (laser) tweezers flow cytometry glycoproteins IIbIIIa inhibition microfluidics
Online Access:	https://www.mdpi.com/2218-273X/10/10/1448