Phylogenomic, structural, and cell biological analyses reveal that Stenotrophomonas maltophilia replicates in acidified Rab7A-positive vacuoles of Acanthamoeba castellanii

ABSTRACTAcanthamoeba species are clinically relevant free-living amoebae (FLA) ubiquitously found in soil and water bodies. Metabolically active trophozoites graze on diverse microbes via phagocytosis. However, functional studies on Rab GTPases (Rabs), which are critical for controlling vesicle traf...

Full description

Bibliographic Details
Published in:	Microbiology Spectrum
Main Authors:	Javier Rivera, Julio C. Valerdi-Negreros, Diana M. Vázquez-Enciso, Fulvia-Stefany Argueta-Zepeda, Pablo Vinuesa
Format:	Article
Language:	English
Published:	American Society for Microbiology 2024-03-01
Subjects:	Acanthamoeba expression plasmids small Rab GTPases endocytic pathway phagocytosis vacuole acidification
Online Access:	https://journals.asm.org/doi/10.1128/spectrum.02988-23

Similar Items

The role of Src kinase in the biology and pathogenesis of <it>Acanthamoeba castellanii</it>
by: Siddiqui Ruqaiyyah, et al.
Published: (2012-06-01)

Cobalt nanoparticles as novel nanotherapeutics against Acanthamoeba castellanii
by: Ayaz Anwar, et al.
Published: (2019-06-01)

The role of the Acanthamoeba castellanii Sir2-like protein in the growth and encystation of Acanthamoeba
by: So-Young Joo, et al.
Published: (2020-07-01)

The in vitro effect riboflavin combined with or without UVA in Acanthamoeba castellanii
by: Joohee Park, et al.
Published: (2024-11-01)

Characterizing clinical isolates of Acanthamoeba castellanii with high resistance to polyhexamethylene biguanide in Taiwan
by: Fu-Chin Huang, et al.
Published: (2017-10-01)

Investigation of In Vitro Amoebicidal Activities of Trachystemon orientalis on Acanthamoeba castellanii Cysts and Trophozoites
by: Bülent Kaynak, et al.
Published: (2019-10-01)

The Activity of Polyhomoarginine against <i>Acanthamoeba castellanii</i>
by: Hari Kumar Peguda, et al.
Published: (2022-11-01)

Antiparasitic properties of miltefosine-based nanoformulations against protozoan pathogen, Acanthamoeba castellanii
by: Noor Akbar, et al.
Published: (2022-01-01)

Ouabain, ATPase inhibitor, potentially enhances the effect of polyhexamethylene biguanide on Acanthamoeba castellanii
by: Kuang-Yi Shih, et al.
Published: (2024-08-01)

In Vitro Stability of the Biological Activity of Voriconazole against <i>Acanthamoeba castellanii</i>
by: Barbara Czerniak Rodrigues, et al.
Published: (2023-06-01)

Effect of environmental stress factors on the uptake and survival of <it>Campylobacter jejuni</it> in <it>Acanthamoeba castellanii</it>
by: Bui Xuan, et al.
Published: (2012-10-01)

In Vitro Effect of Pitavastatin and Its Synergistic Activity with Isavuconazole against <i>Acanthamoeba castellanii</i>
by: Hye Jee Hahn, et al.
Published: (2020-08-01)

A rapid and accurate protocol for quantifying living Acanthamoeba castellanii cysts
by: Kazushi Matsubara, et al.
Published: (2025-10-01)

Experimental Granulomatous Amebic Encephalitis Caused by <i>Acanthamoeba castellanii</i>
by: Samuel da Luz Borges, et al.
Published: (2024-06-01)

Stimulation of Acanthamoeba castellanii excystment by enzyme treatment and consequences on trophozoite growth
by: Zineb Fechtali-Moute, et al.
Published: (2022-09-01)

Identifying the function of genes involved in excreted vesicle formation in Acanthamoeba castellanii containing Legionella pneumophila
by: Min-Jeong Kim, et al.
Published: (2023-06-01)

Potential anti-amoebic effects of synthetic 1,4-benzothiazine derivatives against Acanthamoeba castellanii
by: Alishba, et al.
Published: (2024-01-01)

Establecimiento de protocolos de cultivo y mantenimiento de Acanthamoeba castellanii
by: Daniela Román, et al.
Published: (2024-12-01)

Molecular Characterization and Sequencing of a Gene Encoding Mannose Binding Protein in an Iranian Isolate of Acanthamoeba castellanii as a Major Agent of Acanthamoeba Keratitis
by: SH Farnia, et al.
Published: (2008-07-01)

Unveiling the molecular architecture of the mitochondrial respiratory chain of Acanthamoeba castellanii
by: Christian Q. Scheckhuber, et al.
Published: (2025-03-01)

Encystment and Excystment Processes in <i>Acanthamoeba castellanii</i>: An Emphasis on Cellulose Involvement
by: Mathew Choaji, et al.
Published: (2025-03-01)

Nitroxoline evidence amoebicidal activity against Acanthamoeba castellanii through DNA damage and the stress response pathways
by: Lijun Chen, et al.
Published: (2025-04-01)

Cytochrome P450 monooxygenase of Acanthamoeba castellanii participates in resistance to polyhexamethylene biguanide treatment
by: Huang Jian-Ming, et al.
Published: (2021-01-01)

Modulation of Zinc Homeostasis in Acanthamoeba castellanii as a Possible Antifungal Strategy against Cryptococcus gattii
by: Nicole S. Ribeiro, et al.
Published: (2017-08-01)

Autophagy, Acute Pancreatitis and the Metamorphoses of a Trypsinogen-Activating Organelle
by: Svetlana Voronina, et al.
Published: (2022-08-01)

The Anti-Amoebic Activity of a Peptidomimetic against <i>Acanthamoeba castellanii</i>
by: Hari Kumar Peguda, et al.
Published: (2022-11-01)

Homeostasis of cellular amino acids in Acanthamoeba castellanii exposed to different media under amoeba-bacteria coculture conditions
by: Chih-Ming Tsai, et al.
Published: (2023-07-01)

Antiamoebic Activity of Imidazothiazole Derivatives against Opportunistic Pathogen <i>Acanthamoeba castellanii</i>
by: Noor Akbar, et al.
Published: (2022-08-01)

Comprehensive characterization of extracellular vesicles produced by environmental (Neff) and clinical (T4) strains of Acanthamoeba castellanii
by: Elisa Gonçalves Medeiros, et al.
Published: (2024-06-01)

A Review of Plant Vacuoles: Formation, Located Proteins, and Functions
by: Xiaona Tan, et al.
Published: (2019-09-01)

Acanthamoeba castellanii trophozoites that survive multipurpose solutions are able to adhere to cosmetic contact lenses, increasing the risk of infection
by: Dolores Hernández-Martínez, et al.
Published: (2023-09-01)

Metabolic adaption of Legionella pneumophila during intracellular growth in Acanthamoeba castellanii
by: Mareike Kunze, et al.
Published: (2021-05-01)

Interactions of the emerging fungus Candida auris with Acanthamoeba castellanii reveal phenotypic changes with direct implications on the response to stress and virulence
by: Michele Ramos Valente, et al.
Published: (2025-02-01)

The Autofluorescence Patterns of <i>Acanthamoeba castellanii, Pseudomonas aeruginosa</i> and <i>Staphylococcus aureus</i>: Effects of Antibiotics and Tetracaine
by: Hari Kumar Peguda, et al.
Published: (2021-07-01)

Novel Plant-Based Metabolites as Disinfectants against <i>Acanthamoeba castellanii</i>
by: Ruqaiyyah Siddiqui, et al.
Published: (2022-02-01)

Metronidazole conjugated magnetic nanoparticles loaded with amphotericin B exhibited potent effects against pathogenic Acanthamoeba castellanii belonging to the T4 genotype
by: Sumayah Abdelnasir, et al.
Published: (2020-07-01)

Long-Term Persistence of <i>Yersinia pestis</i> in Association with Acanthamoeba castellanii in Experiment
by: M. A. Makashova, et al.
Published: (2023-02-01)

Disseminated Acanthamoeba castellanii infection in a patient with AIDS: a case report and literature review
by: Qunqun Jiang, et al.
Published: (2024-06-01)

Alternative splicing drives a dynamic transcriptomic response during Acanthamoeba castellanii programmed cell death
by: Jesús Gómez-Montalvo, et al.
Published: (2025-08-01)

Extracellular Vesicles from the Protozoa <i>Acanthamoeba castellanii</i>: Their Role in Pathogenesis, Environmental Adaptation and Potential Applications
by: Diego de Souza Gonçalves, et al.
Published: (2019-02-01)