Exposure–Response Relationship between VWF/FVIII Activity and Spontaneous Bleeding Events Following Recombinant VWF Prophylaxis in Severe VWD

Background Recombinant von Willebrand factor (rVWF, vonicog alfa, Takeda Pharmaceuticals USA) is indicated in adults diagnosed with von Willebrand disease (VWD). In this study, the exposure–response (ER) relationship between VWF activity (VWF:RCo) or factor VIII activity (FVIII:C) and spo...

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Bibliographic Details

Published in:	TH Open
Main Authors:	Frank W.G. Leebeek, Giancarlo Castaman, Jean François Marier, Gülden Özen, Indranil Bhattacharya, Jingmei Zhang, Scarlett Wang, Yi Wang
Format:	Article
Language:	English
Published:	Georg Thieme Verlag KG 2024-04-01
Subjects:	bleeding prophylaxis recombinant VWF vonicog alfa von Willebrand disease factor VIII
Online Access:	http://www.thieme-connect.de/DOI/DOI?10.1055/s-0044-1787815