How Rap and its GEFs control liver physiology and cancer development. C3G alterations in human hepatocarcinoma

Rap proteins regulate liver physiopathology. For example, Rap2B promotes hepatocarcinoma (HCC) growth, while Rap1 might play a dual role. The RapGEF, Epac1, activates Rap upon cAMP binding, regulating metabolism, survival, and liver regeneration. A liver specific Epac2 isoform lacking cAMP-binding d...

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Bibliographic Details

Published in:	Hepatic Oncology
Main Authors:	Celia Sequera, Sara Manzano, Carmen Guerrero, Almudena Porras
Format:	Article
Language:	English
Published:	Taylor & Francis 2018-01-01
Subjects:	C3G Epac hepatocarcinoma liver liver diseases Rap
Online Access:	https://www.futuremedicine.com/doi/10.2217/hep-2017-0026