Comprehensive analysis on subchondral bone marrow lesions of human osteoarthritis by integrating bulk and single-cell transcriptomes

Abstract Objective This study aims to demonstrate the cellular composition and underlying mechanisms in subchondral bone marrow lesions (BMLs) of knee osteoarthritis (OA). Methods BMLs were assessed by MRI Osteoarthritis Knee Score (MOAKS)≥2. Bulk RNA-sequencing (bulk-seq) and BML-specific different...

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Bibliographic Details

Published in:	BMC Musculoskeletal Disorders
Main Authors:	Muhui Zeng, Xiaoshuai Wang, Tianyu Chen, Guangfeng Ruan, Jia Li, Song Xue, Yang Zhao, Zhiyang Hu, Ye Xie, Tianxiang Fan, Shibo Chen, Yang Li, Qianyi Wang, Yue Zhang, Rongkai Zhang, Lijun Lin, Changhai Ding, Zhaohua Zhu
Format:	Article
Language:	English
Published:	BMC 2023-08-01
Subjects:	Osteoarthritis Subchondral bone Bone marrow lesions Deconvolution algorithm Single-cell RNA sequencing
Online Access:	https://doi.org/10.1186/s12891-023-06676-4