Bone Marrow-Derived CD44+ Cells Migrate to Tissue-Engineered Constructs via SDF-1/CXCR4-JNK Pathway and Aid Bone Repair

Background and Aims. Host-derived cells play crucial roles in the regeneration process of tissue-engineered constructs (TECs) during the treatment of large segmental bone defects (LSBDs). However, their identity, source, and cell recruitment mechanisms remain elusive. Methods. A complex model was cr...

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Bibliographic Details

Published in:	Stem Cells International
Main Authors:	Yanzhu Lu, Junchao Xing, Xiaolong Yin, Xiaobo Zhu, Aijun Yang, Jiyue Luo, Jing Gou, Shiwu Dong, Jianzhong Xu, Tianyong Hou
Format:	Article
Language:	English
Published:	Wiley 2019-01-01
Online Access:	http://dx.doi.org/10.1155/2019/1513526