Glycolysis‐Histone Lactylation Crosstalk Drives TXNIP‐NLRP3‐Mediated PANoptosome Assembly and PANoptosis Activation Underlying Diabetic Retinopathy Pathogenesis

ABSTRACT Diabetic retinopathy (DR), a major cause of vision loss in adults, involves aberrant metabolism and inflammation. This study investigated the interplay between glycolysis, histone lactylation, and PANoptosis in DR using human retinal pigment epithelial (RPE) cells under high glucose and dia...

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Bibliographic Details
Published in:MedComm
Main Authors: Xiaoting Xi, Qianbo Chen, Jia Ma, Xuewei Wang, Yuxin Zhang, Qiuxia Xiong, Xiaolei Liu, Yuan Xia, Yan Li
Format: Article
Language:English
Published: Wiley 2025-09-01
Subjects:
diabetic retinopathy
glycolysis
histone lactylation
PANoptosis
thioredoxin interacting protein
Online Access:https://doi.org/10.1002/mco2.70351

Internet

https://doi.org/10.1002/mco2.70351

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