Endothelial c-Myc knockout disrupts metabolic homeostasis and triggers the development of obesity

Introduction: Obesity is a major risk factor associated with multiple pathological conditions including diabetes and cardiovascular disease. Endothelial dysfunction is an early predictor of obesity. However, little is known regarding how early endothelial changes trigger obesity. In the present work...

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Bibliographic Details

Published in:	Frontiers in Cell and Developmental Biology
Main Authors:	Jacqueline F. Machi, Isabella Altilio, Yue Qi, Alejo A. Morales, Diego H. Silvestre, Diana R. Hernandez, Nicolas Da Costa-Santos, Aline G. Santana, Mehrnoosh Neghabi, Parisa Nategh, Thiago L. Castro, João P. Werneck-de-Castro, Mahsa Ranji, Fabiana S. Evangelista, Roberto I. Vazquez-Padron, Ernesto Bernal-Mizrachi, Claudia O. Rodrigues
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-07-01
Subjects:	MYC endothelial dysfunction adiposity metabolism obesity glucose intolerance
Online Access:	https://www.frontiersin.org/articles/10.3389/fcell.2024.1407097/full