Mutagenesis of the Peptide Inhibitor of ASIC3 Channel Introduces Binding to Thumb Domain of ASIC1a but Reduces Analgesic Activity

Acid-sensing ion channels (ASICs), which act as proton-gating sodium channels, have garnered attention as pharmacological targets. ASIC1a isoform, notably prevalent in the central nervous system, plays an important role in synaptic plasticity, anxiety, neurodegeneration, etc. In the peripheral nervo...

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發表在:	Marine Drugs
Main Authors:	Timur A. Khasanov, Ekaterina E. Maleeva, Sergey G. Koshelev, Victor A. Palikov, Yulia A. Palikova, Igor A. Dyachenko, Sergey A. Kozlov, Yaroslav A. Andreev, Dmitry I. Osmakov
格式:	Article
語言:	英语
出版:	MDPI AG 2024-08-01
主題:	acid-sensing ion channel peptide ligand mutagenesis molecular docking pain models analgesic effect
在線閱讀:	https://www.mdpi.com/1660-3397/22/9/382