Osteoblasts and osteoclasts: an important switch of tumour cell dormancy during bone metastasis

Abstract Bone metastasis occurs when tumour cells dissociate from primary tumours, enter the circulation (circulating tumour cells, CTCs), and colonize sites in bone (disseminated tumour cells, DTCs). The bone marrow seems to be a particularly dormancy-inducing environment for DTCs, yet the mechanis...

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Bibliographic Details

Published in:	Journal of Experimental & Clinical Cancer Research
Main Authors:	Rongchen Dai, Mengfan Liu, Xincheng Xiang, Zhichao Xi, Hongxi Xu
Format:	Article
Language:	English
Published:	BMC 2022-10-01
Subjects:	Tumour cell dormancy Osteoclasts Osteoblasts Bone marrow niche Bone metastasis
Online Access:	https://doi.org/10.1186/s13046-022-02520-0