Fluorinated hydroxyapatite conditions a favorable osteo-immune microenvironment via triggering metabolic shift from glycolysis to oxidative phosphorylation

Abstract Background Biological-derived hydroxyapatite is widely used as a bone substitute for addressing bone defects, but its limited osteoconductive properties necessitate further improvement. The osteo-immunomodulatory properties hold crucial promise in maintaining bone homeostasis, and precise m...

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Bibliographic Details

Published in:	Journal of Translational Medicine
Main Authors:	Kaidi Chen, Seongmin Ha, Leyao Xu, Chengwu Liu, Yuanxiang Liu, Xiayi Wu, Zhipeng Li, Shiyu Wu, Bo Yang, Zhuofan Chen
Format:	Article
Language:	English
Published:	BMC 2024-05-01
Subjects:	Metabolic shift Osteo-immunomodulation Bone regeneration Fluoride Macrophages
Online Access:	https://doi.org/10.1186/s12967-024-05261-0