RUNX2 mediated epithelial mesenchymal transition induced by TGF beta and Smad signaling promotes malignant progression in glioma

Abstract RUNX2, a member of the RUNX transcription factor family, has been reported to promote epithelial-mesenchymal transition (EMT) in various malignancies, yet its role in glioma remains poorly understood. In this study, we systematically analyzed RUNX2 expression and clinical relevance in gliom...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Peng Zhou, Qianfeng Wei, Haoqian Wang, Tao Yu, Lin Chen, Qiliang Huang, Li Wei, Jingting Jiang
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-07-01
Subjects:	RUNX2 Glioma EMT TGF-β/Smad pathway Prognosis
Online Access:	https://doi.org/10.1038/s41598-025-09167-9