MicroRNA-1912 regulates cholesterol homeostasis by targeting PCSK9

Proprotein convertase subtilisin/kexin type 9 (PCSK9) binds to low-density lipoprotein (LDL) receptor (LDLR) and promotes degradation of LDLR, regulating cholesterol homeostasis. Previous studies have reported several microRNAs (miRNAs) that regulate PCSK9 expression; however, evidence for these eff...

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Bibliographic Details

Published in:	Molecular Therapy: Nucleic Acids
Main Authors:	Chan Joo Lee, Myeongjune Go, Sae-Bom Jeon, Sun-Ho Lee, Dongkook Min, So Hee Park, Seunghyun Lee, Sahng Wook Park
Format:	Article
Language:	English
Published:	Elsevier 2025-09-01
Subjects:	MT: Non-coding RNAs proprotein convertase subtilisin/kexin type 9 microRNA-1912 hypercholesterolemia cholesterol homeostasis low-density lipoprotein
Online Access:	http://www.sciencedirect.com/science/article/pii/S216225312500143X