Sensitive inference of alignment-safe intervals from biodiverse protein sequence clusters using EMERALD

Abstract Sequence alignments are the foundations of life science research, but most innovation so far focuses on optimal alignments, while information derived from suboptimal solutions is ignored. We argue that one optimal alignment per pairwise sequence comparison is a reasonable approximation whe...

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Bibliographic Details

Published in:	Genome Biology
Main Authors:	Andreas Grigorjew, Artur Gynter, Fernando H. C. Dias, Benjamin Buchfink, Hajk-Georg Drost, Alexandru I. Tomescu
Format:	Article
Language:	English
Published:	BMC 2023-07-01
Subjects:	Sequence alignment Dynamic programming Needleman-Wunsch algorithm Protein folding Suboptimal alignments
Online Access:	https://doi.org/10.1186/s13059-023-03008-6