Effects of a low-dose IL-2 treatment in HLA-B27 transgenic rat model of spondyloarthritis

Abstract Introduction/Aim HLA-B27/human β2m transgenic rats (B27-rats) develop an inflammatory disorder resembling spondyloarthritis (SpA) with dysregulated IL-10/IL-17 production by regulatory T cells (Treg). Treg plays a major role in controlling pathogenic inflammatory processes. Interleukin 2 (I...

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Bibliographic Details

Published in:	Arthritis Research & Therapy
Main Authors:	L. M. Araujo, Q. Jouhault, I. Fert, I. Bouiller, G. Chiocchia, M. Breban
Format:	Article
Language:	English
Published:	BMC 2021-07-01
Subjects:	Low-dose IL-2 HLA-B27 transgenic rat Regulatory T cells Spondyloarthritis
Online Access:	https://doi.org/10.1186/s13075-021-02559-y