Multistep orthophosphate release tunes actomyosin energy transduction

Release of the ATP hydrolysis product orthophosphate (Pi) from the myosin active site is central in force generation but is poorly understood. Here, Moretto et al. present evidence for multistep Pi-release reconciling apparently contradictory results.

Bibliographic Details
Published in:Nature Communications
Main Authors: Luisa Moretto, Marko Ušaj, Oleg Matusovsky, Dilson E. Rassier, Ran Friedman, Alf Månsson
Format: Article
Language:English
Published: Nature Portfolio 2022-08-01
Online Access:https://doi.org/10.1038/s41467-022-32110-9