Palmitoyltransferase ZDHHC6 promotes colon tumorigenesis by targeting PPARγ-driven lipid biosynthesis via regulating lipidome metabolic reprogramming

Abstract Background The failure of proper recognition of the intricate nature of pathophysiology in colorectal cancer (CRC) has a substantial effect on the progress of developing novel medications and targeted therapy approaches. Imbalances in the processes of lipid oxidation and biosynthesis of fat...

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Bibliographic Details

Published in:	Journal of Experimental & Clinical Cancer Research
Main Authors:	Junqi Shan, Xinyu Li, Runqi Sun, Yao Yao, Yan Sun, Qin Kuang, Xianling Dai, Yanlai Sun
Format:	Article
Language:	English
Published:	BMC 2024-08-01
Subjects:	Colorectal cancer (CRC) ZDHHC6 PPARγ Palmitoylation Lysosomal degradation
Online Access:	https://doi.org/10.1186/s13046-024-03154-0