Carvedilol Phenocopies PGC-1α Overexpression to Alleviate Oxidative Stress, Mitochondrial Dysfunction and Prevent Doxorubicin-Induced Toxicity in Human iPSC-Derived Cardiomyocytes

Doxorubicin (DOX), one of the most effective and widely used anticancer drugs, has the major limitation of cancer treatment-related cardiotoxicity (CTRTOX) in the clinic. Reactive oxygen species (ROS) generation and mitochondrial dysfunction are well-known consequences of DOX-induced injury to cardi...

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Bibliographic Details

Published in:	Antioxidants
Main Authors:	Nnamdi Uche, Qiang Dai, Shuping Lai, Kurt Kolander, Mai Thao, Elizabeth Schibly, Xavier Sendaydiego, Jacek Zielonka, Ivor J. Benjamin
Format:	Article
Language:	English
Published:	MDPI AG 2023-08-01
Subjects:	redox homeostasis bioenergetics doxorubicin cardiomyocytes carvedilol prophylaxis
Online Access:	https://www.mdpi.com/2076-3921/12/8/1585