A Genome-Wide CRISPR Interference Screen Reveals an StkP-Mediated Connection between Cell Wall Integrity and Competence in Streptococcus salivarius

ABSTRACT Competence is one of the most efficient bacterial evolutionary and adaptative strategies by synchronizing production of antibacterial compounds and integration of DNA released by dead cells. In most streptococci, this tactic is orchestrated by the ComRS system, a pheromone communication dev...

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Bibliographic Details

Published in:	mSystems
Main Authors:	Adrien Knoops, Alexandra Waegemans, Morgane Lamontagne, Baptiste Decat, Johann Mignolet, Jan-Willem Veening, Pascal Hols
Format:	Article
Language:	English
Published:	American Society for Microbiology 2022-12-01
Subjects:	cell-to-cell communication genome-wide screen quorum sensing DNA transformation ComRS cell wall
Online Access:	https://journals.asm.org/doi/10.1128/msystems.00735-22