Spatially resolved, high-dimensional transcriptomics sorts out the evolution of biphasic malignant pleural mesothelioma: new paradigms for immunotherapy

Abstract Background Malignant Pleural Mesothelioma (MPM) is a dreadful disease escaping the classical genetic model of cancer evolution and characterized by wide heterogeneity and transcriptional plasticity. Clinical evolution of MPM is marked by a progressive transdifferentiation that converts well...

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Bibliographic Details

Published in:	Molecular Cancer
Main Authors:	F Torricelli, B Donati, F Reggiani, V Manicardi, S Piana, R Valli, F Lococo, Alessia Ciarrocchi
Format:	Article
Language:	English
Published:	BMC 2023-07-01
Subjects:	Malignant pleural mesothelioma Cancer heterogeneity Tumor microenvironment Inflammation Epithelial mesenchymal transition Tumor associated Macrophages
Online Access:	https://doi.org/10.1186/s12943-023-01816-9