Inhibitory Effects of Aschantin on Cytochrome P450 and Uridine 5′-diphospho-glucuronosyltransferase Enzyme Activities in Human Liver Microsomes

Aschantin is a bioactive neolignan found in Magnolia flos with antiplasmodial, Ca2+-antagonistic, platelet activating factor-antagonistic, and chemopreventive activities. We investigated its inhibitory effects on the activities of eight major human cytochrome P450 (CYP) and uridine 5′-diphospho-gluc...

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出版年:	Molecules
主要な著者:	Soon-Sang Kwon, Ju-Hyun Kim, Hyeon-Uk Jeong, Yong Yeon Cho, Sei-Ryang Oh, Hye Suk Lee
フォーマット:	論文
言語:	英語
出版事項:	MDPI AG 2016-04-01
主題:	aschantin human liver microsomes time-dependent cytochrome P450 inhibition UDP-glucuronosyltransferase drug interaction
オンライン･アクセス:	http://www.mdpi.com/1420-3049/21/5/554