Protein quality control disruption by PKCβII in heart failure; rescue by the selective PKCβII inhibitor, βIIV5-3.

Myocardial remodeling and heart failure (HF) are common sequelae of many forms of cardiovascular disease and a leading cause of mortality worldwide. Accumulation of damaged cardiac proteins in heart failure has been described. However, how protein quality control (PQC) is regulated and its contribut...

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發表在:	PLoS ONE
Main Authors:	Julio C B Ferreira, Berta Napchan Boer, Max Grinberg, Patricia Chakur Brum, Daria Mochly-Rosen
格式:	Article
語言:	英语
出版:	Public Library of Science (PLoS) 2012-01-01
在線閱讀:	http://europepmc.org/articles/PMC3316563?pdf=render