Transcriptional evidence of reduced BDNF trophic capacity in the post-mortem human midbrain of schizophrenia cases with high inflammation

Abstract Elevated inflammation in the midbrain of ~45% of people with schizophrenia may relate to altered trophic support for neurons. Dopamine neurons require trophic support from Brain-Derived Neurotrophic Factor (BDNF), that signals via the full-length Tropomyosin kinase B receptor (TrkBTK+). The...

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發表在:	Translational Psychiatry
Main Authors:	Jessica J. Chandra, Yunting Zhu, Alice Petty, Yasmine Kostoglou, William X. Haynes, Maree J. Webster, Cynthia S. Weickert
格式:	Article
語言:	英语
出版:	Nature Publishing Group 2025-05-01
在線閱讀:	https://doi.org/10.1038/s41398-025-03359-7