Revealing the role of SPP1+ macrophages in glioma prognosis and therapeutic targeting by investigating tumor-associated macrophage landscape in grade 2 and 3 gliomas

Abstract Background Glioma is a highly heterogeneous brain tumor categorized into World Health Organization (WHO) grades 1–4 based on its malignancy. The suppressive immune microenvironment of glioma contributes significantly to unfavourable patient outcomes. However, the cellular composition and th...

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Bibliographic Details

Published in:	Cell & Bioscience
Main Authors:	Wenshu Tang, Cario W. S. Lo, Wei Ma, Annie T. W. Chu, Amy H. Y. Tong, Brian H. Y. Chung
Format:	Article
Language:	English
Published:	BMC 2024-03-01
Subjects:	Glioma Tumor-associated macrophages TAM-SPP1 EGFR Immune suppression
Online Access:	https://doi.org/10.1186/s13578-024-01218-4