Structural Transition of the Nucleosome during Transcription Elongation

In eukaryotes, genomic DNA is tightly wrapped in chromatin. The nucleosome is a basic unit of chromatin, but acts as a barrier to transcription. To overcome this impediment, the RNA polymerase II elongation complex disassembles the nucleosome during transcription elongation. After the RNA polymerase...

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Bibliographic Details

Published in:	Cells
Main Authors:	Tomoya Kujirai, Haruhiko Ehara, Shun-ichi Sekine, Hitoshi Kurumizaka
Format:	Article
Language:	English
Published:	MDPI AG 2023-05-01
Subjects:	nucleosome chromatin transcription RNA polymerase II histone chaperone FACT
Online Access:	https://www.mdpi.com/2073-4409/12/10/1388