Heterozygous Spink1 Deficiency Promotes Trypsin-dependent Chronic Pancreatitis in MiceSummary
Background & Aims: Heterozygous SPINK1 mutations are strong risk factors for chronic pancreatitis in humans, yet heterozygous disruption of mouse Spink1 yielded no pancreatic phenotype. To resolve this contradiction, we used CRISPR/Cas9-mediated genome editing to generate heterozygous Spink1...
| Published in: | Cellular and Molecular Gastroenterology and Hepatology |
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| Main Authors: | , |
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-01-01
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| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352345X24001152 |