Tspan18 is a novel regulator of the Ca2+ channel Orai1 and von Willebrand factor release in endothelial cells

Ca2+ entry via Orai1 store-operated Ca2+ channels in the plasma membrane is critical to cell function, and Orai1 loss causes severe immunodeficiency and developmental defects. The tetraspanins are a superfamily of transmembrane proteins that interact with specific ‘partner proteins’ and regulate the...

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Bibliographic Details

Published in:	Haematologica
Main Authors:	Peter J. Noy, Rebecca L. Gavin, Dario Colombo, Elizabeth J. Haining, Jasmeet S. Reyat, Holly Payne, Ina Thielmann, Adam B. Lokman, Georgiana Neag, Jing Yang, Tammy Lloyd, Neale Harrison, Victoria L. Heath, Chris Gardiner, Katharine M. Whitworth, Joseph Robinson, Chek Z. Koo, Alessandro Di Maio, Paul Harrison, Steven P. Lee, Francesco Michelangeli, Neena Kalia, G. Ed Rainger, Bernhard Nieswandt, Alexander Brill, Steve P. Watson, Michael G. Tomlinson
Format:	Article
Language:	English
Published:	Ferrata Storti Foundation 2019-09-01
Online Access:	https://haematologica.org/article/view/9055