Safety and efficacy of individualized modified total neoadjuvant therapy for low locally advanced rectal cancer

Abstract Various studies have confirmed the benefits of total neoadjuvant therapy (TNT) for locally advanced rectal cancer (LARC). Nevertheless, preoperative intensive treatment and a long waiting period can lead to significant side effects. This may result in surgical difficulties and a higher comp...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Qing Ye, Changjiang Chen, Shengyuan Liu, Yangming Li, Jinliang Jian, Feng Huang
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-07-01
Subjects:	Locally advanced rectal cancer Induction chemotherapy Consolidation chemotherapy Short-course neoadjuvant radiotherapy Modified total neoadjuvant therapy
Online Access:	https://doi.org/10.1038/s41598-025-12416-6